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The study was further extended by synthesizing a series of ( E )-2-((substitutedphenyl)diazenyl)phenyl-4-methylbenzenesulfonate ( 12a b ) and (E)-2-((substituted phenyl)diazenyl)phenol derivatives ( 12c d ) (Figure 6) and most of the compounds were strongly inhibit the tyrosinase in a dose-dependent manner