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Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial

FOXO4 can regulate expression of the p53-target p21 cip1 in senescent cells (de Keizer et al., 2010) and through p21 cip1 , p53 can induce p16 in4a -independent cell cycle arrest in senescent cells(Di et al., 1994)