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2) This study conducted by the research team of Heffernan et al investigated the biological effects of AOD9604, a synthetic peptide fragment of HGH, in various mouse models, including lean and obese mice, as well as wild-type (WT) and 3-adrenergic receptor knockout (3-KO) mice

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By blocking NNMT, it prevents the methylation reaction that depletes SAM and nicotinamide, thereby preserving both cofactors and restoring the metabolic machinery that NNMT overexpression had suppressed