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Considering c-MET in aspects of cell signaling network through cross-talking with EGFR, VEGFR-2 and other signaling molecules, it is necessary to develop antibodies that are able to inhibit simultaneously two signaling cascades to achieve maximal therapeutic activity [77, 119]

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Recently, two high-throughput screens for cellular factors required for SARS-CoV-2 infection of cultured cells identified retromer and SNX27 as hits, although this may be due to a role in the trafficking of ACE2 37,38

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