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61 One of the most well-known studies of TPE, the double-blind placebo-controlled AD management by albumin replacement (AMBAR) trial, hypothesized that withdrawing plasma might flush A plaque from the brain into the plasma where it could be removed, thereby reducing AD signs and symptoms

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The findings suggest that dysregulation in the excitatory neurotransmission, potentially involving an increased cycling of the Gln-Glu circuit, may contribute to the pathophysiology of ASD

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