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Retatrutide is investigational and not FDA-approved

Eur J Biochem 267:49044911 Krahenbuhl S, Krahenbuhl-Glauser S, Stucki J, Gehr P, Reichen J (1992) Stereological and functional analysis of liver mitochondria from rats with secondary biliary cirrhosis: impaired mitochondrial metabolism and increased mitochondrial content per hepatocyte

Routes: intravenous (IV), intramuscular (IM) Administration frequency: weekly to biweekly Duration: short-term cycles or maintenance protocols Infusion rate must be controlled to minimize adverse reactions

400,401,402 In liver diseases like non-alcoholic fatty liver disease (NAFLD) and cirrhosis, mitochondrial dysfunction leads to impaired fatty acid oxidation, excessive ROS production, and oxidative stress