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Here is the honest evidence status up front: the individual compounds have real human data Tesamorelin is an FDA-approved prescription drug (EGRIFTA) for HIV-associated lipodystrophy, and Ipamorelin has been characterized in human GH-release studies but the fixed Tesamorelin + Ipamorelin blend as sold for research has no completed human randomized controlled trial of its own
BPC-157 has a molecular weight of approximately 1,419 Daltons, consisting of 15 amino acids with the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Elevated insulin suppresses hormone-sensitive lipase (the enzyme that releases fatty acids from adipocytes), so even though NAD+ rises and sirtuins activate, there's no substrate available to oxidize
The ODT formulation may produce slightly less dramatic results due to lower bioavailability, though individual responses vary considerably
