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At the same time, IGFBP-3, the binding protein of IGF-1, can regulate the IGF-1 activity in tissues to some extent, and the molar ratio of IGF-1/IGF-BP-3 can unveil the number of IGF-1 with biological activity [30, 31, 32]

Given its lower plasma exposure, TLC-2716 was selected for clinical evaluation in the treatment of severe dyslipidemias and related disorders

But injectable delivery is more potent for systemic anti-aging effects it reaches every tissue in the body, not just the surface layers of skin where a cream is applied

doi:10.1016/s0278-6915(01)00034-5 Rangboo V, Noroozi M, Zavoshy R, Rezadoost SA, Mohammadpoorasl A