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Multiple sclerosis-secondary progressive multi-arm randomisation trial (MS-SMART): a multiarm phase IIbrandomised, double-blind, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis

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For example, N-acetylcysteine (NAC), a potent antioxidant, has been examined in clinical trials of NPC disease, which shows increased oxidative stress and dysfunctional autophagy (Wheeler and Sillence, 2020)

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