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Animal studies have demonstrated that local injection of TMAO can exacerbate AF progression in a rapid atrial pacing (RAP)-induced AF model

The therapeutic effect was strongest for formulations having higher levels of EPA, which is known to reduce oxidative stress (Mori et al., 2003)

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In contrast, the survival of mice expressing a hHPN RS was similar to that of the vector-control group (AAV-EGFP), with all mice succumbing within approximately 60 h (Fig