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[DOI] [PubMed] [Google Scholar] 33.Chiou L.-C., Liao Y.-Y., Fan P.-C., Kuo P.-H., Wang C.-H., Riemer C., Prinssen E

Essential elements include HPLC (High Performance Liquid Chromatography) purity testing showing 98% or higher purity, mass spectrometry confirming correct molecular identity, and endotoxin testing ensuring bacterial contamination remains within safe limits

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According to many studies (200, 210212), the process begins by replacing protons on the mineral surface with charged cations such as K + , Na + , and Ca 2+