Although in vitro studies with artificial substrates failed to show an impact of the expansion of the polyQ segment of ATXN3 on its DUB activity [37, 73, 74], the insolubility and immobile nature of the inclusions in vivo [75] may make mutant ATXN3 less prompt to locate at the sites at which editing of Ub chains is needed
While it gives a subtle glow boost on application, patience pays off if youre looking for long-term, more dramatic brightening
Tomson T, Battino D, Bonizzoni E, Craig J, Lindhout D, Perucca E, et al
Independent groups have observed consistent patterns across the published research record, providing cross-laboratory replication for the core mechanism findings documented in the foundational papers cited above