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Upon stimulation, Nrf2 is translocated into the nucleus after dissociation from Keap1 (Itoh et al., 1999)

However, the disparity between mechanistic promise and clinical maturity has direct implications for patient counselling, trial design, regulatory oversight, and ethical considerations surrounding the off-label and grey-market use of these therapies

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Utilizing a targeted search of databases including PubMed, Web of Science, Cochrane Library, Embase, CNKI, and Wanfang Data, we summarize recent findings and examine astragaloside IVs potential applications in arrhythmia prevention and treatment