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2 There is insufficient data to recommend other formulations of vitamin B 12 replacement (e.g., nasal, sublingual, subcutaneous)

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The microglial branch KYN 3-monooxygenase (KMO) metabolizes KYN into 3-hydroxykynurenine (3-HK), which can then follow two main metabolic routes: conversion into 3-hydroxyanthranilic acid (3-HAA) via kynureninase or transformation into xanthurenic acid through KAT

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