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Nevertheless, there is currently a lack of OA-specific genetic models validating the FSP1 or DHODH targets, as well as systematic research on the expression profiles and activity distribution of these pathways in different tissues such as cartilage, synovium, and subchondral bone

Most excluded studies examined glutathione in specific clinical contexts (melasma treatment, postinflammatory hyperpigmentation) rather than addressing general skin health in aging populations

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the apoptosis-regulating proteins Bcl-2 and Bax, the protein phosphatases PP2A and PPP1C, and the cell division control protein Cdc-42 [120]