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From a mechanistic standpoint, glutathione participates in: Neutralization of reactive oxygen species Recycling of other antioxidants such as vitamin C and vitamin E Phase II metabolic pathways Regulation of protein structure through thiol group maintenance Cellular signaling related to immune modulation Mitochondrial energy processes These overlapping roles help explain why glutathione appears frequently in discussions of chronic oxidative burden and inflammatory stress patterns

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It has been shown that TNF- secretion by MoDCs following the introduction of mRNA harboring ac4C is less pronounced compared to unmodified mRNA, and in some cases, comparable to background levels