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Study of the Skin-penetration Promoting Effect and Mechanism of Combined System of Curcumin Liposomes Prepared by Microfluidic Chip and Skin Penetrating Peptides TD-1 for Topical Treatment of Primary Melanoma
[115] described that phosphoglycerate dehydrogenase (PHGDH), involved in the synthesis of serine and glycine from glucose, is critical for pancreatic tumor cells proliferation and tumorigenesis, mediating cell-tight junctions formation, mTOR activation (through Akt), and protein expression and translation, after interaction with the translation initiation factors eIF4A1 and eIF4E (which seems to be independent of its enzymatic activity)
Absolute quantification was performed using isotope-labelled internal standards and validated calibration curves to ensure analytical accuracy and reproducibility
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