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O., Brekhova, M

By subcontracting their R&D activities, pharma and biotech companies are reforming the drug development facilities business

Retatrutide , developed by Eli Lilly, is a novel triple agonist that simultaneously activates three receptors: GLP-1 (glucagon-like peptide-1) receptor reduces appetite and slows gastric emptying GIP (glucose-dependent insulinotropic polypeptide) receptor enhances insulin secretion

These therapies display higher efficiency compared to classical senolytic drugs (BCL-2 or tyrosine kinase inhibitors) but for some of them, such as NA + /K + ATPase inhibitors, clinical development could be complex in the light of strong cardiotoxicity associated with this class of molecules