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The 2016 Zubair trial with 50 Pakistani women represents the only placebo-controlled study, showing 37.5% completion rate versus 18.7% placebo (p=0.054), which failed to reach statistical significance

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PMID: 33711021 Keywords Alpha Sympathomimetics Brimonidine Trade Names: Alphagan-P, Qoliana, Lumify & generic FDA approved in 1996 Drug Class: Alpha-2 Selective Adrenergic Agonist, Antiglaucoma, Vascular decongestant Mechanism of Action: 2 adrenoreceptor agonist approximately 10-times more selective for alpha-2 receptors compared to clonidine (Cambridge, 1981) does not exhibit significant tachyphylaxis with repeated use (Lee & Kim, 2022) Indications: Prescription & OTC to treat symptoms of: open-angle glaucoma : to lower intraocular pressure or ocular hypertension (Alphagan-P, Qoliana )

These merge to accompany the hepatic artery and bile ducts throughout the liver