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52,54-56 A three-month study of a supplement containing a mixture of curcuminoids (at 0.43 mg per 1,000 kilocalories in the diet) plus hydrolyzed collagen and green tea extract in 42 adult dogs with osteoarthritis found the supplement did not improve lameness or owners subjective assessment of mobility, but significantly reduced veterinarians subjective assessment of pain upon movement of affected limbs
Several factors can lead to the uncontrolled production of ROS, including damage to the mitochondrial complex I and III, which are the major sources of ROS, reduced ATP production, or malfunctioning of enzymes such as superoxide dismutase (SOD) that convert ROS into non-toxic molecules (Elfawy and Das, 2019)
The evidence is unambiguous