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We speculated that the observed lipid-reducing activity of bicyclol [25,26] might be due to the induction of GSTA1 expression and thus analyzed the direct effect of bicyclol on GSTA1 expression in cells

Interestingly, the observation that other amino acids than V12 and F112 can principally support flavonoid binding is also reflected in the more relaxed amino acid conservation in native arGSTFs at these two positions (Fig