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However, regardless of the specifics of the study design, participants safety should always be an utmost priority when conducting an FIH trial

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It's interesting to note that p38 inhibition blocked imidazole propionates inhibitory effect on acute metformin action, suggesting possible therapy options for T2D patients who do not respond well to metformin (Koh et al., 2020)

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doi:10.1136/pgmj.60.707.636

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