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Integr Biol (Camb) , 8 (3), 319331

10.1007/BF00687767 Acta Neuropathol

10.1002/jcu.22916 14

Monitoring Response Patients or research participants typically notice: Appetite suppression within the first 12 weeks Early satiety and slower gastric emptying by weeks 34 Weight loss trends becoming evident by week 8 Continued improvements in glucose metabolism when paired with semaglutide or tirzepatide Side Effects and Considerations Common side effects include: Nausea Mild gastrointestinal discomfort Constipation Injection site reactions These effects are generally transient and dose-dependent, which is why titration is important