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Cuproptosis increases the stability of NFE2L2 by suppressing its proteasomal degradation, leading to transcriptional upregulation of GCLC and GCLM and enhanced GSH synthesis, thereby suppressing cuproptosis in pancreatic cancer cells 169

However, HIF-1 also upregulates the production of anti-inflammatory cytokines like IL-10, creating a complex regulatory network that can either exacerbate or alleviate inflammation depending on the context

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