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2.6.4 ER-stress markers Inositol-requiring enzyme 1 (IRE1), a marker of ER stress, was identified in the tissue homogenate utilizing a rat ELISA kit (Shanghai YL Biotech, Shanghai, China)

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While these can reduce inflammation, they often bring difficult side effects: Weight gain, bloating, and bone loss Increased infection risk Fatigue and mood changes High long-term costs Because these drugs suppress the immune system instead of balancing it, flare-ups frequently return once treatment stops