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Since DMF is metabolized by intestinal esterases to monomethylfumarate (MMF), novel MMF derivative compounds with greater efficacy, bioavailability, and reduced side effects are currently under investigation in preclinical studies, including VCB102 compound for psoriasis, and VCB101 compound for MS

Timing considerations include taking calcium supplements separately from iron supplements (if prescribed) by at least two hours, as these minerals compete for absorption

Ensuring quality, safety, and effectiveness is vital

Funding This study was supported by grants from the National Natural Science Foundation of China (Grant Nos