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Vitamin C Vitamin C is a water-soluble compound that exists in seminal plasma at a concentration 10 times higher than in blood serum.[41] The rationale behind its use stems from its ability to neutralize hydroxyl, superoxide, and hydrogen peroxide radicals, thus providing protection against endogenous oxidative damage.[42] Lower Vitamin C levels and higher ROS levels were observed in the seminal plasma of men with asthenozoospermia.[43] Moreover, Vitamin C had a significant positive correlation, in a dose-dependent manner, with sperm motility[44] and percentage of normal sperm morphology.[45] Vitamin C was mainly investigated in combination with other vitamins and minerals.[19,46] Of particular interest was the combination of Vitamins C and E as the hydrophilicity of the former and lipophilicity of the latter is believed to have a synergistic effect in reducing peroxidative damage on spermatozoa.[46] Such a hypothesis was not confirmed in a randomized controlled double-blind study conducted on men with iOAT, where Rolf et al

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