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Furthermore, the transcription factor KLF9 suppresses GM3 biosynthesis by inhibiting ST3GAL5 expression through direct binding to its proximal promoter and distal enhancer [62]

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13% of the participants treated with the combined compound ended up discontinuing the trial, while 10% of the participants treated with semaglutide discontinued, however, none of the participants treated with cagrilintide discontinued their treatment plan indicating that cagrilintide was the most well tolerated by the study participants [2]

however, its activator can be utilized to reduce the stemness of TNBC cells and enhance treatment sensitivity to paclitaxel