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Dysfunctions of AFG3L2 have been linked to neurodegenerative diseases such as dominant optic atrophy 33 and PINK1-mediated mitochondrial fission 34 , though its role in cancer remains under-investigated

The sirtuin family member SIRT-1 is a protein lysine deacetylase that regulates several physiological processes, including energy production, inflammatory responses, cell survival, DNA repair, tissue regeneration, and stress responses

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