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Next.... nature.com/articles/s4157 The evolving landscape of obesity pharmacotherapy Nature Reviews Drug Discovery, 2026 1 Obesity pharmacotherapy has moved from weight loss drugs to cardiometabolic disease-modifying therapy Obesity is now framed as a chronic, relapsing, neuroendocrine-metabolic disease, not simply a lifestyle failure

As a result, DHAR regenerates a pool of reduced ascorbate and detoxifies reactive oxygen species (ROS)

Ferroptosis caused by microbiota dysbiosis can be inhibited by early-life gut microbiota-derived ether lipids (plasmalogens), which also influence susceptibility to colitis [89]