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These findings underscore a significant therapeutic perspective: by implementing substantial immunomodulatory effects, these botanical agents engage biological mechanisms that are not comprehensively addressed by traditional antidepressant treatments

Still, in a frozen state, the tissues were homogenized using a Potters homogenizer (1100 rpm, 1.5 min), where the exact ratio of 5mL ice-cold ACN: H 2 O (1:1, vol.) to 1 g of tissue was kept

Cultured cells were treated similarly

While ALK inhibition itself can trigger an LC3B-independent macroautophagic flux that promotes the survival of EML4-ALK+ cells (136), strategically inducing autophagy in a controlled manner can be beneficial