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Interestingly, recent work showed that CA-MRSA strains produce significantly more WTA content than HA-MRSA or laboratory strains 69 , suggesting that WTA expression may be an important factor in mediating resistance to CS-TSB and an important prerequisite for MRSA colonisation in smokers

This increased incidence has been shown after a variety of DNA damage mechanisms, such as ionizing radiation (strand breaks), alkylation by methyl-methane sulfonate (MMS), ultraviolet irradiation (photodimers), and a variety of environmental carcinogens