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There is also an increased sensitization of the excitatory neurotransmitter system, such as NMDA glutamate receptors, the reduction in the number of GABA receptors (downregulation), the shift of benzodiazepine receptors to an inverse agonist state, and compensatory changes in other components of the macromolecular GABA/benzodiazepine/chloride ionophore complex (for review see, i.e., [219,220,221,222,223,224,225])

Zhu X, Sakamoto S, Ishii C, Smith MD, Ito K, Obayashi M, et al

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It is also well known that the guarana seeds reduce the appetite which makes the final product - complex composition and free of any negative side effects