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The first e-liquids used a type of nicotine called freebase, which is renowned for providing a throat hit, especially at higher strengths, when vaping

Nine months earlier, as his trial in the United States District Court for the Southern District of Iowa reached the halfway point, Stephen Carrie Blumberg had invited me to spend a Saturday with him in Ottumwa, the city where he had been arrested by a squad of federal agents

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This behavioral priming may pave the way for subsequent use of nicotine-containing substances, aligning with the gateway hypothesis