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Unlike sepsis, where treatments are primarily directed against LPS-induced inflammatory responses (e.g., anti-endotoxin antibodies), SAP-induced glycocalyx damage is predominantly driven by pancreatic enzyme activation (e.g., trypsin) and intestinal endotoxin release

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Frey II, a pioneer in intranasal central nervous system (CNS) delivery and adjunct professor at the University of Minnesota, explained it perfectly: We proved you could noninvasively deliver stem cells to the brain from the nose