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To the best of our knowledge, the present study is the first to show that uric acid affected NO levels in VSMCs in a dose- and time-independent manner, while also providing comprehensive evidence that uric acid increased superoxide anion levels at 1, 3, 6, 12 and 24 h, with a less pronounced increase at 3 h compared with the other time points, and its dose-dependent effects on protein carbonyl levels

With its excellent safety profile and ease of administration, epithalon may be administered twice annually in two short courses for its anti-aging effects

Second, it argues against a pure placebo effect, because placebo responses tend to diminish more gradually

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