Preclinical data consistently show low cytotoxicity, minimal immune activation, and reduced issues related to anti-PEG antibodies, making POx attractive for repeated dosing and long-circulating formulations
Furthermore, alignment analysis also demonstrated that Asn (N), Gly (G), Arg (R), Pro (P), Thr (T), Tyr (Y), Lys (K), Ala-Ser (AS), Cys-Gly (CG), Phe-Pro (FP), Glu-Pro (EP), Leu-Lys (LK), Lys-Phe (KF), Asn-Gly (NG), Asn-Gln-Phe (NQF), and Trp-Asn-Phe (WNF) residues were strictly conserved in all aligned sequences, indicating their potential functions in enzyme activity and/or stability (Supplementary Figure S3)
4.) Durchfhrung von Enzymreaktionen, da diese nur ablaufen knnen, wenn ausreichend Glutathion zur Verfgung steht
Shackelford C, Long G, Wolf J, Okerberg C, Herbert R