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For each analysis, the statistical test used and n for each group are found in Supplemental Tables 2, 3, or 5

GLP-1 agonists primarily reduce appetite and slow digestion, leading to reduced calorie intake

Mineral Blend: Includes magnesium, zinc, manganese, and copper and is intended for IM injection or IV infusion only

Significant main effects of treatment group (prior to BenjaminiHochberg correction since none were significant after correction, although the necessity of correction for multiple comparisons in exploratory analyses remains unresolved 49 ) were observed for the unclassified group and ten classified genera, namely, Acetatifactor , Akkermansia , Erysipelatoclostridium , [ Eubacterium ] coprostanoligenes group , Family XIII UCG-001 , Lactobacillus , Parasutterella , Ruminiclostridium 6 , Ruminococcaceae UCG-004 , and Ruminococcaceae UCG-009