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508,509 Bumetanide, an NKCC1 (Na + -K + -2Cl cotransporter) chloride-importer inhibitor that reduces (Cl ) i levels, enhances GABAergic inhibition, which improves the behavioural symptoms of individuals with ASD

A provider may also consider whether inflammation, injury history, immune status, medication use, or underlying conditions require a different starting point

Dosing Protocol A suggested daily approach based on preclinical reference doses for this NNMT inhibitor

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