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Funding: Supported by NIH grants P30 DK056341 (Washington University Nutrition and Obesity Research Center), P30 DK020579 (Washington University Diabetes Research Center), UL1 TR000448 (Washington University Institute of Clinical and Translational Sciences), and T32 DK007120, and the Barnes-Jewish Hospital Foundation

The absence of serious adverse events, treatment-related withdrawals, IGF-1 elevation, glucose metabolism impairment, or immunogenic responses represents a favorable safety foundation

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