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In this work, we demonstrate that HSV infection induces an early production of ROS, which regulates the activation of innate immune responses initiated by HSV infection, via TLRs, RLRs, and IFI16

doi: 10.1016/j.scitotenv.2020.142015 6 AhamadA.KumarJ

In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 100%, or higher than 100%, compared to an otic formulation that is not a controlled-release otic formulation

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