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The difference between elevated or unchanged GLP-1 levels in obese patients may be related to differences in metabolic status and detection methods, but the significant correlation between GLP-1 and lipid metabolism suggests that it can control weight and regulate lipid metabolism in HF diet groups, and GLP-1 has the potential to treat obesity caused by HF diet [102]

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Major components of the hormetic response include various stress resistance proteins, such as heat-shock proteins (HSPs), antioxidants, and growth factors [210,212,221]