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However, those with kidney disease or G6PD deficiency should avoid high doses

A study in the Journal of Clinical Biochemistry says, Vitamin B12 deficiency can cause big problems with nerves and blood. Vitamin B12 is key for making DNA, fatty acids, and energy. Source: Journal of Clinical Biochemistry Common Signs of Deficiency A Vitamin B12 shortage can show in many ways, like: Fatigue and weakness Numbness or tingling in hands and feet Difficulty walking Mood changes, such as depression Spotting these signs early is key for quick action

Taking stomach acid-lowering drugs : Medications can block absorption, including antacids used to treat conditions like gastritis or esophageal reflux and antihistamines

This effect can cause or worsen gastroparesis