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First, it disrupts the process of melanin synthesis by inducing the release of high mobility group box 1 (HMGB1) protein, thus downregulating the melanin biosynthesis-related proteins: melanocyte-inducing transcription factor, tyrosinase, tyrosinase-related protein-1, tyrosinase-related protein-2, RAB27A and fascin actin-bundling protein 1 [17, 18]

Related article: Glutathione synthesis and genetic variants Once a toxic substance has been conjugated with glutathione via the GST-specific enzyme, the body excretes it via bile or urine

To enhance its effectiveness, it is often recommended to pair oral glutathione with Vitamin C

This reinforced the need for comprehensive sun protection that works from the inside out