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We then built the isobologram of the corresponding dose-response curves with a fixed dose ratio of R and compared the expected mixture of the two doses that produced an effect equal to half of the maximal effect produced by the individual drugs and to the experimental value (see later in methods)

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For IBS specifically, pooled incidence rates reach 10% at 6 months but drop to 3% at 12 months, suggesting some cases may resolve spontaneously