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Diabetologia 60 , 16391647 (2017)

To gain insights into the mechanism of VERO cell toxicity at high compound concentrations, the compounds were tested for inhibition of human cytoplasmic TrxR1 and GR

Overall, this network-based analysis highlights interconnected metabolic and gene regulatory pathways that may contribute to ASD-associated metabolic dysregulation and offers a systems-level framework for prioritizing pathways for future mechanistic and validation studies

Figure 3 3.2 Integrated immune metabolic regulation of ferroptosis Ferroptosis involves aberrant iron metabolism, resulting in lipid peroxidation and the degradation of cellular membranes