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Because SLC7A11 exchanges intracellular glutamate with extracellular cystine, the intracellular glutamate concentration decreases, which leads to more Gln uptake and increased glutaminase activity and making these cells dependent on external Gln

The binding of 6-AH analogs to HGF was assessed by competition using a soluble binding assay

Specifically, the deletion of TrkB in iSPNs elevated the expression of Gsto2 , thereby leading to increased dopamine levels through alterations of ascorbic acid homeostasis and disruption of energy metabolism in the neurons

doi: 10.1111/jdv.14792 18 LiuZPouliDAlonzoCAVaroneAKaraliotaSQuinnKPet al