When NRF2 is hyperactive, it drives the expression of metallothioneins, small cysteine-rich proteins that avidly bind zinc, copper, and cadmium, effectively acting as a metal buffer that soaks up drugs like cisplatin which form platinum-DNA adducts, sequestering them before they can do harm
That "lessons from one tissue applied to another" idea is a big part of why the compound is so intriguing to people who treat injuries for a living
Reprod Toxicol 63:112 Rajeh N, Ali H, ElAssouli S (2014) Protective effects of 5-aminosalicylic acid on acrylamide toxicity in the testis and blood leukocytes of the rat
And blood glucose level was measured at 0, 3, 6, 9, 12, 15, 30 min after i.p