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Fatigue or feeling cold during fast weight loss Fewer cravings for alcohol, snacks, or junk food (commonly reported) When to Slow Down or Stop Vomiting that does not stop within 24 hours Severe upper abdominal pain that wraps around to the back Yellowing of skin or eyes Severe dehydration signs (dizziness, very dark urine, racing heart) Rapid weight loss over 2 lb per week sustained for many weeks (lean tissue loss risk) 13

Storage: Reconstituted peptide solutions should generally be stored in a refrigerator at 28C and protected from light Avoid freezing the reconstituted solution In-use shelf life must follow product-specific validated stability data

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Such a postulation has strong support based on the outcome from claudin-2 TG mice, which are resistant to colitis