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Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy

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At high doses or when combined with other drugs, the liver is no longer able to produce enough glutathione to neutralize all the NAPQI, leading to inflammation, oxidative stress and, ultimately, liver failure

it potentially has a role for liver and kidney support under oxidative stress conditions where those tissues can utilize extracellular GSH more directly